Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life.

Molecular and cellular biology - 1 Aug 2007

Smith Florentia M, Holt Lowenna J, Garfield Alastair S, Charalambous Marika, Koumanov Francoise, Perry Mark, Bazzani Reto, Sheardown Steven A, Hegarty Bronwyn D, Lyons Ruth J, Cooney Gregory J, Daly Roger J, Ward Andrew

Abstract excerpt

The Grb10 adapter protein is capable of interacting with a variety of receptor tyrosine kinases, including, notably, the insulin receptor. Biochemical and cell culture experiments have indicated that Grb10 might act as an inhibitor of insulin signaling. We have used mice with a disruption of the Grb10 gene (Grb10Delta2-4 mice) to assess whether Grb10 might influence insulin signaling and glucose homeostasis in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue, White
Share to Adiposity

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Body Composition

Share to Feeding Behavior

Share to Leptin

Share to Phosphotyrosine

Share to Receptor, IGF Type 1

Share to Receptor, Insulin

Source

Open in PubMed Open full text

Identifiers

PMID: 17562854
DOI: 10.1128/MCB.02087-06
PMCID: PMC1952119

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life.PMID 17562854Read ↗

Grb10 and Grb14: enigmatic regulators of insulin action--and more?Semantic proximity Read ↗

Imprinted <i>Grb10</i> , encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor ( <i>Igf1r</i> ) and insulin receptor ( <i>Insr</i> ) genesSemantic proximity Read ↗

Developmental Programming Mediated by Complementary Roles of Imprinted Grb10 in Mother and PupSemantic proximity Read ↗

Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism.Semantic proximity Read ↗

Growth factor receptor-binding protein 10 (Grb10) as a partner of phosphatidylinositol 3-kinase in metabolic insulin action.Semantic proximity Read ↗

A central role for GRB10 in regulation of islet function in man.Semantic proximity Read ↗

The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts.Semantic proximity Read ↗

Antagonistic roles in fetal development and adult physiology for the oppositely imprinted Grb10 and Dlk1genesSemantic proximity Read ↗

Maternally-inherited Grb10 reduces placental size and efficiency.Semantic proximity Read ↗

De-silencing Grb10 contributes to acute ER stress-induced steatosis in mouse liverSemantic proximity Read ↗

Inhibition of Grb14, a negative modulator of insulin signaling, improves glucose homeostasis without causing cardiac dysfunctionSemantic proximity Read ↗

Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and RegenerationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.