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Article

Grb10 and Grb14: enigmatic regulators of insulin action--and more?

The Biochemical journal - 1 Jun 2005

Holt Lowenna J, Siddle Kenneth

Abstract excerpt

The Grb proteins (growth factor receptor-bound proteins) Grb7, Grb10 and Grb14 constitute a family of structurally related multidomain adapters with diverse cellular functions. Grb10 and Grb14, in particular, have been implicated in the regulation of insulin receptor signalling, whereas Grb7 appears predominantly to be involved in focal adhesion kinase-mediated cell migration. However, at least in vitro, these...

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Identifiers

PMID: 15901248
DOI: 10.1042/BJ20050216
PMCID: PMC1138946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Grb10 and Grb14: enigmatic regulators of insulin action--and more?PMID 15901248Read ↗

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The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts.Semantic proximity Read ↗

Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14.Semantic proximity Read ↗

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Imprinted <i>Grb10</i> , encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor ( <i>Igf1r</i> ) and insulin receptor ( <i>Insr</i> ) genesSemantic proximity Read ↗

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