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Article

Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jul 2003

Charalambous Marika, Smith Florentia M, Bennett William R, Crew Tracey E, Mackenzie Francesca, Ward Andrew

Abstract excerpt

To investigate the function of the Grb10 adapter protein, we have generated mice in which the Grb10 gene was disrupted by a gene-trap insertion. Our experiments confirm that Grb10 is subject to genomic imprinting with the majority of Grb10 expression arising from the maternally inherited allele. Consistent with this, disruption of the maternal allele results in overgrowth of both the embryo and placenta such that...

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Source

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Identifiers

PMID: 12829789
DOI: 10.1073/pnas.1532175100
PMCID: PMC166222

Genes

GRB10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism.PMID 12829789Read ↗

Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life.Semantic proximity Read ↗

Imprinting of human GRB10 and its mutations in two patients with Russell-Silver syndrome.Semantic proximity Read ↗

Maternally-inherited Grb10 reduces placental size and efficiency.Semantic proximity Read ↗

Maternal repression of the human GRB10 gene in the developing central nervous system; evaluation of the role for GRB10 in Silver-Russell syndrome.Semantic proximity Read ↗

Imprinted <i>Grb10</i> , encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor ( <i>Igf1r</i> ) and insulin receptor ( <i>Insr</i> ) genesSemantic proximity Read ↗

Developmental Programming Mediated by Complementary Roles of Imprinted Grb10 in Mother and PupSemantic proximity Read ↗

Evidence against GRB10 as the gene responsible for Silver-Russell syndrome.Semantic proximity Read ↗

Large de novo deletion of 7p15.1 to 7p12.1 involving the imprinted gene GRB10 associated with a complex phenotype including features of Beckwith Wiedemann syndrome.Semantic proximity Read ↗

Heterogeneous growth patterns in carriers of chromosome 7p12.2 imbalances affecting GRB10.Semantic proximity Read ↗

Identification of the <i>Meg1</i> / <i>Grb10</i> imprinted gene on mouse proximal chromosome 11, a candidate for the Silver–Russell syndrome geneSemantic proximity Read ↗

Distinct physiological and behavioural functions for parental alleles of imprinted Grb10.Semantic proximity Read ↗

Human GRB10 is imprinted and expressed from the paternal and maternal allele in a highly tissue- and isoform-specific fashion.Semantic proximity Read ↗

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