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Article

Multisite phosphorylation of C-Nap1 releases it from Cep135 to trigger centrosome disjunction.

Journal of cell science - 1 Jun 2014

Hardy Tara, Lee Miseon, Hames Rebecca S, Prosser Suzanna L, Cheary Donna-Marie, Samant Mugdha D, Schultz Francisca, Baxter Joanne E, Rhee Kunsoo, Fry Andrew M

Abstract excerpt

During mitotic entry, centrosomes separate to establish the bipolar spindle. Delays in centrosome separation can perturb chromosome segregation and promote genetic instability. However, interphase centrosomes are physically tethered by a proteinaceous linker composed of C-Nap1 (also known as CEP250) and the filamentous protein rootletin. Linker disassembly occurs at the onset of mitosis in a process known as...

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Identifiers

PMID: 24695856
DOI: 10.1242/jcs.142331
PMCID: PMC4038944

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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