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Article

Phosphorylation of Nup98 by multiple kinases is crucial for NPC disassembly during mitotic entry.

Cell - 18 Feb 2011

Laurell Eva, Beck Katja, Krupina Ksenia, Theerthagiri Gandhi, Bodenmiller Bernd, Horvath Peter, Aebersold Ruedi, Antonin Wolfram, Kutay Ulrike

Abstract excerpt

Disassembly of nuclear pore complexes (NPCs) is a decisive event during mitotic entry in cells undergoing open mitosis, yet the molecular mechanisms underlying NPC disassembly are unknown. Using chemical inhibition and depletion experiments we show that NPC disassembly is a phosphorylation-driven process, dependent on CDK1 activity and supported by members of the NIMA-related kinase (Nek) family. We identify...

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Source

Identifiers

PMID: 21335236
DOI: 10.1016/j.cell.2011.01.012

Genes

CDK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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