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Article

Separate domains of KAR1 mediate distinct functions in mitosis and nuclear fusion.

The Journal of cell biology - 1 Jun 1992

Vallen E A, Hiller M A, Scherson T Y, Rose M D

Abstract excerpt

The yeast KAR1 gene is essential for mitotic growth and important for nuclear fusion. Mutations in KAR1 prevent duplication of the spindle pole body (SPB), and affect functions associated with both the nuclear and cytoplasmic microtubules. The localization of hybrid Kar1-lacZ proteins, described elsewhere (Vallen, E. A., T. Y. Scherson, T. Roberts, K. van Zee, and M. D. Rose. 1992. Cell. In press), suggest that...

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Identifiers

PMID: 1607389
DOI: 10.1083/jcb.117.6.1277
PMCID: PMC2289497

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