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Article

Separate domains of KAR1 mediate distinct functions in mitosis and nuclear fusion.

The Journal of cell biology - 1 Jun 1992

Vallen E A, Hiller M A, Scherson T Y, Rose M D

Abstract excerpt

The yeast KAR1 gene is essential for mitotic growth and important for nuclear fusion. Mutations in KAR1 prevent duplication of the spindle pole body (SPB), and affect functions associated with both the nuclear and cytoplasmic microtubules. The localization of hybrid Kar1-lacZ proteins, described elsewhere (Vallen, E. A., T. Y. Scherson, T. Roberts, K. van Zee, and M. D. Rose. 1992. Cell. In press), suggest that...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Cell Nucleus
Chromosome Deletion
DNA, Fungal
Fungal Proteins
Genetic Complementation Test
Mitosis
Molecular Sequence Data
Multigene Family

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nuclear Proteins

Phenotype

Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 1607389
DOI: 10.1083/jcb.117.6.1277
PMCID: PMC2289497

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1607389-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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