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Article

Cell cycle regulation by the NEK family of protein kinases

1 Jan 2012

Abstract excerpt

Genetic screens for cell division cycle mutants in the filamentous fungus Aspergillus nidulans led to the discovery of never-in-mitosis A (NIMA), a serine/threonine kinase that is required for mitotic entry. Since that discovery, NIMA-related kinases, or NEKs, have been identified in most eukaryotes, including humans where eleven genetically distinct proteins named NEK1 to NEK11 are expressed. Although there is...

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PMID: 23132929
DOI: 10.1242/jcs.111195

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Cell cycle regulation by the NEK family of protein kinasesPMID 23132929Read ↗

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How protein kinases co-ordinate mitosis in animal cellsSemantic proximity Read ↗

On Broken Ne(c)ks and Broken DNA: The Role of Human NEKs in the DNA Damage ResponseSemantic proximity Read ↗

Nek7 kinase is enriched at the centrosome, and is required for proper spindle assembly and mitotic progression.Semantic proximity Read ↗

Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors.Semantic proximity Read ↗

Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells.Semantic proximity Read ↗

Role of the cell-cycle-regulated NIMA protein kinase during G2 and mitosis: evidence for two pathways of mitotic regulation.Semantic proximity Read ↗

Targeting NEK2 as a promising therapeutic approach for cancer treatmentSemantic proximity Read ↗

Evidence for a NIMA-like mitotic pathway in vertebrate cells.Semantic proximity Read ↗

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