Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis.

Cell - 6 Jul 2012

Asencio Claudio, Davidson Iain F, Santarella-Mellwig Rachel, Ly-Hartig Thi Bach Nga, Mall Moritz, Wallenfang Matthew R, Mattaj Iain W, Gorjánácz Mátyás

Abstract excerpt

Mitosis in metazoa requires nuclear envelope (NE) disassembly and reassembly. NE disassembly is driven by multiple phosphorylation events. Mitotic phosphorylation of the protein BAF reduces its affinity for chromatin and the LEM family of inner nuclear membrane proteins; loss of this BAF-mediated chromatin-NE link contributes to NE disassembly. BAF must reassociate with chromatin and LEM proteins at mitotic exit...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carrier Proteins

Share to HeLa Cells

Share to Mitosis

Share to Nuclear Envelope

Share to Protein Phosphatase 2

Share to Protein Serine-Threonine Kinases

Source

Identifiers

PMID: 22770216
DOI: 10.1016/j.cell.2012.04.043

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis.PMID 22770216Read ↗

Caenorhabditis elegans BAF-1 and its kinase VRK-1 participate directly in post-mitotic nuclear envelope assembly.Semantic proximity Read ↗

Mechanisms of PP2A-Ankle2 dependent nuclear reassembly after mitosisSemantic proximity Read ↗

Dephosphorylation of barrier-to-autointegration factor by protein phosphatase 4 and its role in cell mitosis.Semantic proximity Read ↗

Cyclin B1-Cdk1 facilitates MAD1 release from the nuclear pore to ensure a robust spindle checkpoint.Semantic proximity Read ↗

Barrier-to-autointegration factor phosphorylation on Ser-4 regulates emerin binding to lamin A in vitro and emerin localization in vivo.Semantic proximity Read ↗

Multiple Requirements of PLK1 during Mouse Oocyte MaturationSemantic proximity Read ↗

The vaccinia-related kinases phosphorylate the N' terminus of BAF, regulating its interaction with DNA and its retention in the nucleus.Semantic proximity Read ↗

Dbf2-Mob1 drives relocalization of protein phosphatase Cdc14 to the cytoplasm during exit from mitosis.Semantic proximity Read ↗

Barrier-to-autointegration factor plays crucial roles in cell cycle progression and nuclear organization in Drosophila.Semantic proximity Read ↗

A role for gp210 in mitotic nuclear-envelope breakdown.Semantic proximity Read ↗

Ste20‐like kinase activity promotes meiotic resumption and spindle microtubule stability in mouse oocytesSemantic proximity Read ↗

The yeast polo kinase Cdc5 regulates the shape of the mitotic nucleus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.