Article
Erroneous identification of APOBEC3-edited chromosomal DNA in cancer genomics.
British journal of cancer - 13 May 2014
Suspène R, Caval V, Henry M, Bouzidi M S, Wain-Hobson S, Vartanian J-P
Abstract excerpt
BACKGROUND: The revolution in cancer genomics shows that the dominant mutations are CG->TA transitions. The sources of these mutations are probably two host cell cytidine deaminases APOBEC3A and APOBEC3B. The former in particular can access nuclear DNA and monotonously introduce phenomenal numbers of C->T mutations in the signature 5'TpC context. These can be copied as G->A transitions in the 5'GpA context....
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