Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

APOBEC-mediated Mutagenesis as a Likely Cause of FGFR3 S249C Mutation Over-representation in Bladder Cancer

8 Apr 2019

Abstract excerpt

FGFR3 is one of the most frequently mutated genes in bladder cancer and a driver of an oncogenic dependency. Here we report that only the most common recurrent FGFR3 mutation, S249C (TCC→TGC), represents an APOBEC-type motif and is probably caused by the APOBEC-mediated mutagenic process, accounting for its over-representation. We observed significant enrichment of the APOBEC mutational signature and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bladder and Urothelial Cancer Treatments
Share to Epigenetics and DNA Methylation
Share to Fibroblast Growth Factor Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30975452
DOI: 10.1016/j.eururo.2019.03.032

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

APOBEC-mediated Mutagenesis as a Likely Cause of FGFR3 S249C Mutation Over-representation in Bladder CancerPMID 30975452Read ↗

The cytidine deaminase APOBEC3G drives cancer mutagenesis and clonal evolution in bladder cancerSemantic proximity Read ↗

Isoform-specific characterization implicates alternative splicing in <i>APOBEC3B</i> as a mechanism restricting APOBEC-mediated mutagenesisSemantic proximity Read ↗

APOBEC-mediated mutagenesis in urothelial carcinoma is associated with improved survival, mutations in DNA damage response genes, and immune responseSemantic proximity Read ↗

Analysis of Several Common APOBEC-type Mutations in Bladder Tumors Suggests Links to Viral Infection.Semantic proximity Read ↗

Association of germline variants in the APOBEC3 region with cancer risk and enrichment with APOBEC-signature mutations in tumors.Semantic proximity Read ↗

APOBEC3-mediated mutagenesis in cancer: causes, clinical significance and therapeutic potential.Semantic proximity Read ↗

APOBEC-mediated mutagenesis in urothelial carcinoma is associated with improved survival, mutations in DNA damage response genes, and immune responseSemantic proximity Read ↗

Mechanisms of APOBEC3 mutagenesis in human cancer cellsSemantic proximity Read ↗

The interesting relationship between APOBEC3 deoxycytidine deaminases and cancer: a long road ahead.Semantic proximity Read ↗

Identification of new driver and passenger mutations within APOBEC-induced hotspot mutations in bladder cancer.Semantic proximity Read ↗

APOBEC3B, a molecular driver of mutagenesis in human cancersSemantic proximity Read ↗

APOBEC3A Catalyzes Mutation and Drives Carcinogenesis <i>In Vivo</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.