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Article

Role of the polycystins as mechanosensors of extracellular stiffness.

American journal of physiology. Renal physiology - 1 May 2021

Nigro Elisa A, Boletta Alessandra

Abstract excerpt

Polycystin-1 (PC-1) is a transmembrane protein, encoded by the PKD1 gene, mutated in autosomal dominant polycystic kidney disease (ADPKD). This common genetic disorder, characterized by cyst formation in both kidneys, ultimately leading to renal failure, is still waiting for a definitive treatment. The overall function of PC-1 and the molecular mechanism responsible for cyst formation are slowly coming to light,...

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Share to Extracellular Matrix
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mechanotransduction, Cellular

Share to Polycystic Kidney, Autosomal Dominant

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Identifiers

PMID: 33615892
DOI: 10.1152/ajprenal.00545.2020

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