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Polycystic Kidney Disease

23 Oct 2008

Abstract excerpt

A number of inherited disorders result in renal cyst development. The most common form, autosomal dominant polycystic kidney disease (ADPKD), is a disorder most often diagnosed in adults and caused by mutation in PKD1 or PKD2. The PKD1 protein, polycystin-1, is a large receptor-like protein, whereas polycystin-2 is a transient receptor potential channel. The polycystin complex localizes to primary cilia and may...

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PMID: 18947299
DOI: 10.1146/annurev.med.60.101707.125712

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