Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Autosomal dominant polycystic kidney disease: clues to pathogenesis.

Human molecular genetics - 1 Jan 1999

Harris P C

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutation of one of two genes: PKD1 (16p13.3) or PKD2 (4q13-23). PKD1 accounts for approximately 85% of pedigrees and is associated with significantly more severe cystic disease. The ADPKD genes encode proteins, polycystin-1 and polycystin-2, which are very different in size and structure, but which have a region of homology and may interact as part...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Heterogeneity
Share to Multigene Family
Share to Polycystic Kidney, Autosomal Dominant

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Proteins

Share to Repressor Proteins

Share to TRPP Cation Channels

Share to Tuberous Sclerosis Complex 2 Protein

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 10469838
DOI: 10.1093/hmg/8.10.1861

Genes

PKD1
PKD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Autosomal dominant polycystic kidney disease: clues to pathogenesis.PMID 10469838Read ↗

Molecular and cellular pathogenesis of autosomal dominant polycystic kidney disease.Semantic proximity Read ↗

The polycystins: a novel class of membrane-associated proteins involved in renal cystic disease.Semantic proximity Read ↗

Genetics and Pathogenesis of Polycystic Kidney DiseaseSemantic proximity Read ↗

Molecular basis of autosomal-dominant polycystic kidney disease.Semantic proximity Read ↗

Molecular pathogenesis of ADPKD: the polycystin complex gets complex.Semantic proximity Read ↗

The etiology, pathogenesis, and treatment of autosomal dominant polycystic kidney disease: recent advances.Semantic proximity Read ↗

A polycystin-centric view of cyst formation and disease: the polycystins revisited.Semantic proximity Read ↗

Genetics and pathogenesis of autosomal dominant polycystic kidney disease: 20 years on.Semantic proximity Read ↗

Molecular basis of autosomal dominant polycystic kidney disease.Semantic proximity Read ↗

New insights into polycystic kidney disease and its treatment.Semantic proximity Read ↗

Autosomal dominant polycystic kidney disease (ADPKD, MIM 173900, PKD1 and PKD2 genes, protein products known as polycystin-1 and polycystin-2).Semantic proximity Read ↗

Molecular genetics of polycystic kidney disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.