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Article

Regulation of RNA polymerase II termination by phosphorylation of Gdown1.

The Journal of biological chemistry - 2 May 2014

Guo Jiannan, Turek Michael E, Price David H

Abstract excerpt

Gdown1 is a substoichiometric subunit of RNA polymerase II (Pol II) that has been recently demonstrated to be involved in stabilizing promoter-proximal paused Pol II. It was shown to inhibit termination of Pol II by transcription termination factor 2 (TTF2) as well as block elongation stimulation by transcription factor IIF (TFIIF). Here, using in vitro transcription assays, we identified two functional domains...

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Identifiers

PMID: 24634214
DOI: 10.1074/jbc.M113.537662
PMCID: PMC4007455

Genes

TTF2
SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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