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Article

Total apolipoprotein E levels and specific isoform composition in cerebrospinal fluid and plasma from Alzheimer's disease patients and controls.

Acta neuropathologica - 1 May 2014

Martínez-Morillo Eduardo, Hansson Oskar, Atagi Yuka, Bu Guojun, Minthon Lennart, Diamandis Eleftherios P, Nielsen Henrietta M

Abstract excerpt

The apolipoprotein E (ApoE) ε4 allele is the strongest risk factor of sporadic Alzheimer's disease (AD), however, the fluid concentrations of ApoE and its different isoforms (ApoE2, ApoE3 and ApoE4) in AD patients and among APOE genotypes (APOE ε2, ε3, ε4) remain controversial. Using a novel mass spectrometry-based method, we quantified total ApoE and specific ApoE isoform concentrations and potential...

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Source

Identifiers

PMID: 24633805
DOI: 10.1007/s00401-014-1266-2

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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