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Article

The apolipoprotein E ε4 allele plays pathological roles in AD through high protein expression and interaction with butyrylcholinesterase.

Neurobiology of aging - 1 Jul 2011

Darreh-Shori Taher, Modiri Negar, Blennow Kaj, Baza Souad, Kamil Chelenk, Ahmed Hiba, Andreasen Niels, Nordberg Agneta

Abstract excerpt

The apolipoprotein E (ApoE) ε4 allele has consistently been established as an Alzheimer's disease (AD) risk factor, but its pathological contribution to AD is obscure. Certain butyrylcholinesterase (BuChE) polymorphisms together with the ApoE ε4 allele synergistically increase the risk of AD. In addition, AD risk factors, i.e. advanced age, female gender and ApoE ε4 are associated with different levels of CSF...

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Source

Identifiers

PMID: 19713000
DOI: 10.1016/j.neurobiolaging.2009.07.015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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