Article
APOE epsilon 3/ epsilon 4 heterozygotes have an elevated proportion of apolipoprotein E4 in cerebrospinal fluid relative to plasma, independent of Alzheimer's disease diagnosis.
Experimental neurology - 1 Sept 2003
Fukumoto Hiroaki, Ingelsson Martin, Gårevik Nina, Wahlund Lars Olof, Nukina Nobuyuki, Yaguchi Yoshio, Shibata Masao, Hyman Bradley T, Rebeck G William, Irizarry Michael C
Abstract excerpt
Inheritance of the apolipoprotein E (APOE) epsilon 4 allele is associated with an increased risk of Alzheimer's disease (AD). However, the risk of AD in APOE epsilon 3/ epsilon 4 heterozygotes is variable. We tested the hypothesis that the risk of AD in APOE epsilon 3/ epsilon 4 heterozygotes was linked to the relative levels of expression of apoE4 versus apoE3 protein. We measured the apoE4 isoform and total...
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