Article
APOE epsilon 3/ epsilon 4 heterozygotes have an elevated proportion of apolipoprotein E4 in cerebrospinal fluid relative to plasma, independent of Alzheimer's disease diagnosis.
Experimental neurology - 1 Sept 2003
Fukumoto Hiroaki, Ingelsson Martin, Gårevik Nina, Wahlund Lars Olof, Nukina Nobuyuki, Yaguchi Yoshio, Shibata Masao, Hyman Bradley T, Rebeck G William, Irizarry Michael C
Abstract excerpt
Inheritance of the apolipoprotein E (APOE) epsilon 4 allele is associated with an increased risk of Alzheimer's disease (AD). However, the risk of AD in APOE epsilon 3/ epsilon 4 heterozygotes is variable. We tested the hypothesis that the risk of AD in APOE epsilon 3/ epsilon 4 heterozygotes was...
Topics
- Age of Onset
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Apolipoprotein E3
- Apolipoprotein E4
- Apolipoproteins E
- Cohort Studies
- Female
- Genotype
- Heterozygote
- Humans
- Male
- Massachusetts