Article

Impact of APOE ε3 and ε4 genotypes on plasma proteome signatures in Alzheimer’s disease

2022-01-31

Abstract excerpt

The ε 4 allele of the apolipoprotein E ( APOE ) gene is a high-risk factor for Alzheimer’s disease (AD). However, approximately 25%–40% of patients with AD do not carry the APOEε4 allele, and the pathophysiological mechanisms underlying AD are less evident in these individuals. The main objective of this study was to understand better the changes in plasma that may contribute to disease pathogenesis in AD and h...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ad90e181-045f-5d1d-a9ea-27767c0994e8
DOI: 10.1101/2022.01.29.478291

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Impact of APOE ε3 and ε4 genotypes on plasma proteome signatures in Alzheimer’s diseaseDOI 10.1101/2022.01.29.478291Read

Impact of APOE ε3 and ε4 genotypes on plasma proteome signatures in Alzheimer's diseaseSemantic proximity Read

Serum proteomics reveals early biomarkers of Alzheimer's disease: The dual role of APOE-ε4Semantic proximity Read

APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer's disease.Semantic proximity Read

Serum proteomics reveal APOE-ε4-dependent and APOE-ε4-independent protein signatures in Alzheimer’s diseaseSemantic proximity Read

Proteomic signatures of the APOE ε4 and APOE ε2 genetic variants and Alzheimer's disease.Semantic proximity Read

Proteomic Signatures of Protected <i>APOE</i> -ε4 Carriers Reveal Causal Pathways Associated with Delayed Alzheimer’s Disease OnsetSemantic proximity Read

Plasma proteomics of <i>APOE</i> genotype: age-specific analyses in UK population-based cohortsSemantic proximity Read

Proteome profiling of cerebrospinal fluid using machine learning shows a unique protein signature associated with APOE4 genotype.Semantic proximity Read

Serum proteomics reveals<i>APOE</i>dependent and independent protein signatures in Alzheimer’s diseaseSemantic proximity Read

Proteome profiling of cerebrospinal fluid using machine learning shows a unique protein signature associated with APOE4 genotypeSemantic proximity Read

Serum proteomics reveals APOE dependent and independent protein signatures in Alzheimer’s diseaseSemantic proximity Read

Plasma Proteomic Analysis of <i>APOE</i> ε4 Homozygotes Identifies Preclinical Alzheimer’s Disease Alterations Potentially Modulated by SemaglutideSemantic proximity Read