Article
Two putative acetyltransferases, san and deco, are required for establishing sister chromatid cohesion in Drosophila.
Current biology : CB - 2 Dec 2003
Williams Byron C, Garrett-Engele Carrie M, Li Zexiao, Williams Erika V, Rosenman Elizabeth D, Goldberg Michael L
Abstract excerpt
BACKGROUND: Sister chromatid cohesion is needed for proper alignment and segregation of chromosomes during cell division. Chromatids are linked by the multiprotein cohesin complex, which binds to DNA during G(1) and then establishes cohesion during S phase DNA replication. However, many aspects of the mechanisms that establish and maintain cohesion during mitosis remain unclear. RESULTS: We found that mutations...
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