Genetic polymorphisms of DAT1 and COMT differentially associate with actigraphy-derived sleep-wake cycles in young adults.

doi:10.3109/07420528.2014.896376

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Article

Genetic polymorphisms of DAT1 and COMT differentially associate with actigraphy-derived sleep-wake cycles in young adults.

Chronobiology international - 1 Jun 2014

Valomon Amandine, Holst Sebastian C, Bachmann Valérie, Viola Antoine U, Schmidt Christina, Zürcher Jurian, Berger Wolfgang, Cajochen Christian, Landolt Hans-Peter

Abstract excerpt

Accumulating evidence suggests that dopamine plays a key role in sleep-wake regulation. Cerebral dopamine levels are regulated primarily by the dopamine transporter (DAT) in the striatum and by catechol-O-methyl-transferase (COMT) in the prefrontal cortex. We hypothesized that the variable-number-tandem-repeat (VNTR) polymorphism in the 3'-untranslated region of the gene encoding DAT (DAT1, SLC6A3; rs28363170)...

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PMID: 24625311
DOI: 10.3109/07420528.2014.896376

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COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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