Effects of Acute Caffeine Intake on Insulin-Like Growth Factor-1 Responses to Total Sleep Deprivation: Interactions with COMT Polymorphism - A Randomized, Crossover Study.

doi:10.1159/000529897

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Article

Effects of Acute Caffeine Intake on Insulin-Like Growth Factor-1 Responses to Total Sleep Deprivation: Interactions with COMT Polymorphism - A Randomized, Crossover Study.

Lifestyle genomics - 1 Jan 2023

Drogou Catherine, Sauvet Fabien, Erblang Mégane, Leger Damien, Thomas Claire, Chennaoui Mounir, Gomez-Merino Danielle

Abstract excerpt

INTRODUCTION: Genes encoding catechol-O-methyl-transferase (COMT) and adenosine A2A receptor (ADORA2A) have been shown to influence cognitive performances and responses to caffeine intake during prolonged wakefulness. The rs4680 single-nucleotide polymorphism (SNP) of COMT differentiates on memory score and circulating levels of the neurotrophic factor IGF-1. This study aimed to determine the kinetics of IGF-1,...

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PMID: 37279709
DOI: 10.1159/000529897

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