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Article

Acute antidepressant response to sleep deprivation combined with light therapy is influenced by the catechol-O-methyltransferase Val(108/158)Met polymorphism.

Journal of affective disorders - 1 Feb 2010

Benedetti Francesco, Barbini Barbara, Bernasconi Alessandro, Fulgosi Mara Cigala, Dallaspezia Sara, Gavinelli Chiara, Locatelli Clara, Lorenzi Cristina, Pirovano Adele, Radaelli Daniele, Smeraldi Enrico, Colombo Cristina

Abstract excerpt

Catechol-O-methyltransferase (COMT) inactivates norepinephrine and dopamine via methyl conjugation, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity. It is a current area of debate whether rs4680 can influence antidepressant response in major depressive disorder, and whether this influence extends to bipolar depression. Chronotherapeutic interventions, such as sleep deprivation and...

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Source

Identifiers

PMID: 19520435
DOI: 10.1016/j.jad.2009.05.017

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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