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Article

Dopaminergic role in regulating neurophysiological markers of sleep homeostasis in humans.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 8 Jan 2014

Holst Sebastian C, Bersagliere Alessia, Bachmann Valérie, Berger Wolfgang, Achermann Peter, Landolt Hans-Peter

Abstract excerpt

While dopamine affects fundamental brain processes such as movement control, emotional responses, addiction, and pain, the roles for this neurotransmitter in regulating wakefulness and sleep are incompletely understood. Genetically modified animal models with reduced dopamine clearance exhibit hypersensitivity to caffeine, reduced-responsiveness to modafinil, and increased homeostatic response to prolonged...

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Identifiers

PMID: 24403155
DOI: 10.1523/JNEUROSCI.4128-13.2014
PMCID: PMC6608156

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