Time to wake up: No impact of COMT Val158Met gene variation on circadian preferences, arousal regulation and sleep.

doi:10.1080/07420528.2016.1178275

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Article

Time to wake up: No impact of COMT Val158Met gene variation on circadian preferences, arousal regulation and sleep.

Chronobiology international - 1 Jan 2016

Jawinski Philippe, Tegelkamp Sophie, Sander Christian, Häntzsch Madlen, Huang Jue, Mauche Nicole, Scholz Markus, Spada Janek, Ulke Christine, Burkhardt Ralph, Reif Andreas, Hegerl Ulrich, Hensch Tilman

Abstract excerpt

Dopamine has been implicated in the regulation of sleep-wake states and the circadian rhythm. However, there is no consensus on the impact of two established dopaminergic gene variants: the catechol-O-methyltransferase Val158Met (COMT Val158Met; rs4680) and the dopamine D4 receptor Exon III variable-number-of-tandem-repeat polymorphism (DRD4 VNTR). Pursuing a multi-method approach, we examined their potential...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27148829
DOI: 10.1080/07420528.2016.1178275

Genes

COMT
DRD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Time to wake up: No impact of COMT Val158Met gene variation on circadian preferences, arousal regulation and sleep.PMID 27148829Read ↗

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