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Article

Catechol-O-Methyltransferase Genotype and Gait Speed Changes over 10 Years in Older Adults.

Journal of the American Geriatrics Society - 1 Sept 2017

Metti Andrea L, Rosano Caterina, Boudreau Robert, Massa Robyn, Yaffe Kristine, Satterfield Suzanne, Harris Tamara, Rosso Andrea L

Abstract excerpt

OBJECTIVES: To determine the association between catechol-O-methyltransferase (COMT) genotype and 6-m walk time and to determine whether these associations are quadratic in nature, similar to previously reported U-shaped associations between dopamine and gait and cognition. DESIGN: Prospective cohort study. SETTING: Health, Aging and Body Composition Study. PARTICIPANTS: Black (n = 850) and white (n = 1,352) men...

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PMID: 28640434
DOI: 10.1111/jgs.14980
PMCID: PMC5603384

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COMT

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