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Article

Catechol-O-methyltransferase (COMT) genotype affects cognitive control during total sleep deprivation.

Cortex; a journal devoted to the study of the nervous system and behavior - 1 Feb 2018

Satterfield Brieann C, Hinson John M, Whitney Paul, Schmidt Michelle A, Wisor Jonathan P, Van Dongen Hans P A

Abstract excerpt

Adaptive decision making is profoundly impaired by total sleep deprivation (TSD). This suggests that TSD impacts fronto-striatal pathways involved in cognitive control, where dopamine is a key neuromodulator. In the prefrontal cortex (PFC), dopamine is catabolized by the enzyme catechol-O-methyltransferase (COMT). A functional polymorphism (Val158Met) influences COMT's enzymatic activity, resulting in markedly...

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Identifiers

PMID: 29248857
DOI: 10.1016/j.cortex.2017.11.012
PMCID: PMC5801055

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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