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Article

Ecto-5'-nucleotidase and thiopurine cellular circulation: association with cytotoxicity.

Drug metabolism and disposition: the biological fate of chemicals - 1 Dec 2010

Li Fang, Fridley Brooke L, Matimba Alice, Kalari Krishna R, Pelleymounter Linda, Moon Irene, Ji Yuan, Jenkins Gregory D, Batzler Anthony, Wang Liewei, Weinshilboum Richard M

Abstract excerpt

Thiopurine drugs such as 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG) are used to treat acute lymphoblastic leukemia of childhood. To test the hypothesis that variation in the expression of genes within the "thiopurine pathway" might influence 6-MP and 6-TG sensitivity, we generated basal gen...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20855458
DOI: 10.1124/dmd.110.035220
PMCID: PMC2993460

Genes

ABCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20855458-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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