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Pathway genes and metabolites in thiopurine therapy in Korean children with acute lymphoblastic leukaemia

30 Mar 2019

Abstract excerpt

AIMS: We aimed to investigate the impact of various genetic polymorphisms affecting thiopurine metabolism pathways and toxicity in paediatric acute lymphoblastic leukaemia patients for the first time in Korea. METHODS: From May 2006 to September 2016, 139 paediatric acute lymphoblastic leukaemia patients treated with combination chemotherapy including 6-mercaptopurine were included in the study. One hundred and...

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PMID: 30927276
DOI: 10.1111/bcp.13943

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