PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity.

doi:10.1093/hmg/dds302

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Article

PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity.

Human molecular genetics - 1 Nov 2012

Stocco Gabriele, Yang Wenjian, Crews Kristine R, Thierfelder William E, Decorti Giuliana, Londero Margherita, Franca Raffaella, Rabusin Marco, Valsecchi Maria Grazia, Pei Deqing, Cheng Cheng, Paugh Steven W, Ramsey Laura B, Diouf Barthelemy, McCorkle Joseph Robert, Jones Terreia S, Pui Ching-Hon, Relling Mary V, Evans William E

Abstract excerpt

Treatment-related toxicity can be life-threatening and is the primary cause of interruption or discontinuation of chemotherapy for acute lymphoblastic leukemia (ALL), leading to an increased risk of relapse. Mercaptopurine is an essential component of continuation therapy in all ALL treatment protocols worldwide. Genetic polymorphisms in thiopurine S-methyltransferase (TPMT) are known to have a marked effect on...

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Identifiers

PMID: 22846425
DOI: 10.1093/hmg/dds302
PMCID: PMC3471396

Genes

TPMT
PACSIN2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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