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Article

Genetic and epigenetic variants contributing to clofarabine cytotoxicity.

Human molecular genetics - 1 Oct 2013

Eadon Michael T, Wheeler Heather E, Stark Amy L, Zhang Xu, Moen Erika L, Delaney Shannon M, Im Hae Kyung, Cunningham Patrick N, Zhang Wei, Dolan M Eileen

Abstract excerpt

2-chloro-2-fluoro-deoxy-9-D-arabinofuranosyladenine (Clofarabine), a purine nucleoside analog, is used in the treatment of hematologic malignancies and as induction therapy for stem cell transplantation. The discovery of pharmacogenomic markers associated with chemotherapeutic efficacy and toxicity would greatly benefit the utility of this drug. Our objective was to identify genetic and epigenetic variants...

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Adaptor Proteins, Signal Transducing
Adenine Nucleotides
Apoptosis Regulatory Proteins
Black People
Cytosine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pharmacogenetics

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Identifiers

PMID: 23720496
DOI: 10.1093/hmg/ddt240
PMCID: PMC3766179

Genes

BAG3
KLHL6
SETBP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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