Effects of NT5C2 Germline Variants on 6-Mecaptopurine Metabolism in Children With Acute Lymphoblastic Leukemia.

doi:10.1002/cpt.2095

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Article

Effects of NT5C2 Germline Variants on 6-Mecaptopurine Metabolism in Children With Acute Lymphoblastic Leukemia.

Clinical pharmacology and therapeutics - 1 Jun 2021

Jiang Chuang, Yang Wenjian, Moriyama Takaya, Liu Chengcheng, Smith Colton, Yang Wentao, Qian Maoxiang, Li Ziping, Tulstrup Morten, Schmiegelow Kjeld, Crews Kristine R, Zhang Hui, Pui Ching-Hon, Evans William, Relling Mary, Bhatia Smita, Yang Jun J

Abstract excerpt

6-mercaptopurine (6-MP) is widely used in the treatment of acute lymphoblastic leukemia (ALL), and its cytotoxicity is primarily mediated by thioguanine nucleotide (TGN) metabolites. A recent genomewide association study has identified germline polymorphisms (e.g., rs72846714) in the NT5C2 gene associated with 6-MP metabolism in patients with ALL. However, the full spectrum of genetic variation in NT5C2 is...

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PMID: 33124053
DOI: 10.1002/cpt.2095
PMCID: PMC8081740

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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