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Article

Pharmacogenetic evaluation of 6-mercaptopurine-mediated toxicity in pediatric acute lymphoblastic leukemia patients from a South Indian population.

Pharmacogenomics - 1 May 2021

Ramalingam Ravi, Kaur Harpreet, Scott Julius Xavier, Sneha Latha M, Arun Kumar Ganesh Prasad, Srinivasan Arathi, Paul Solomon Fd

Abstract excerpt

Aim: To evaluate the variants in the genes coding for the proteins involved in thiopurine and folate metabolism with treatment related adverse effects (TRAEs). Materials & methods: Eleven variants in seven candidate genes were genotyped in 127 pediatric acute lymphoblastic leukemia patients under 6-mercaptopurine (6-MP) treatment to infer the association of selected genotypes with TRAEs. Results: Among the...

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Identifiers

PMID: 33876659
DOI: 10.2217/pgs-2020-0193

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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