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Article

Unraveling Novel Genetic Determinants of Thiopurine Response Via TWAS.

Clinical pharmacology and therapeutics - 1 Jan 2026

Bidoli Carlotta, Yang Wenjian, Karol Seth E, Lucafò Marianna, Stocco Gabriele, Yang Jun J

Abstract excerpt

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Thiopurines such as 6-mercaptopurine (6MP) are essential in ALL maintenance therapy. However, dose-limiting toxicities can significantly disrupt treatment. While genetic variants in TPMT and NUDT15 are known to affect thiopurine response, many patients with normal function genotypes in these genes still experience adverse effects, suggesting...

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Topics

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Share to Antimetabolites, Antineoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40908865
DOI: 10.1002/cpt.70053
PMCID: PMC12746518

Genes

GNAQ
NUDT15
TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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