Article

Effects of <i>NT5C2</i> germline variants on 6-mecaptopurine metabolism in children with acute lymphoblastic leukemia

2020-10-14

Abstract excerpt

6-mercaptopurine (6-MP) is widely used in the treatment of acute lymphoblastic leukemia (ALL), and its cytotoxicity is primarily mediated by thioguanine nucleotide metabolites (TGN). Recent genome-wide association study has identified germline polymorphisms (e.g., rs72846714) in the NT5C2 gene associated with 6-MP metabolism in patients with ALL. However, the full spectrum of genetic variation in NT5C2 is unclea...

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Literature Corpus work: 06109353-b137-59c2-b753-33f9115ee2f5
DOI: 10.1101/2020.10.13.338384

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