Article
Mutagen sensitivity as measured by induced chromatid breakage as a marker of cancer risk.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2014
Wu Xifeng, Zheng Yun-Ling, Hsu T C
Abstract excerpt
Risk assessment is now recognized as a multidisciplinary process, extending beyond the scope of traditional epidemiologic methodology to include biological evaluation of interindividual differences in carcinogenic susceptibility. Modulation of environmental exposures by host genetic factors may explain much of the observed interindividual variation in susceptibility to carcinogenesis. These genetic factors...
Topics
- 4-Nitroquinoline-1-oxide
- 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
- Bleomycin
- Cells, Cultured
- Chromatids
- DNA Breaks, Double-Stranded
- Genetic Markers
- Genetic Predisposition to Disease
- Humans
- Lymphocytes
- Mutagens
- Neoplasms
- Quinolones
- Radiation Injuries
- Risk
