Article
In vitro sensitivity to ultraviolet B light and skin cancer risk: a case-control analysis.
Journal of the National Cancer Institute - 21 Dec 2005
Wang Li-E, Xiong Ping, Strom Sara S, Goldberg Leonard H, Lee Jeffrey E, Ross Merrick I, Mansfield Paul F, Gershenwald Jeffrey E, Prieto Victor G, Cormier Janice N, Duvic Madeleine, Clayman Gary L, Weber Randal S, Lippman Scott M, Amos Christopher I, Spitz Margaret R, Wei Qingyi
Abstract excerpt
BACKGROUND: Mutagen sensitivity, measured as mutagen-induced chromatid breaks per cell in primary lymphocytes in vitro, has been used to study susceptibility to various epithelial cancers. Patients with xeroderma pigmentosum are highly sensitive to ultraviolet (UV) light due to inherited defects in DNA repair and have a 1000-fold higher risk of UV-induced skin cancer than the general population. However, an...
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