Article
Mutagen sensitivity has high heritability: evidence from a twin study.
Cancer research - 15 Jun 2006
Wu Xifeng, Spitz Margaret R, Amos Christopher I, Lin Jie, Shao Lina, Gu Jian, de Andrade Mariza, Benowitz Neal L, Shields Peter G, Swan Gary E
Abstract excerpt
Despite numerous studies showing that mutagen sensitivity is a cancer predisposition factor, the heritability of mutagen sensitivity has not been clearly established. In this report, we used a classic twin study design to examine the role of genetic and environmental factors on the mutagen sensitivity phenotype. Mutagen sensitivity was measured in peripheral blood lymphocytes from 460 individuals [148 pairs of...
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