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Article

Genetic polymorphisms of DNA repair and xenobiotic-metabolizing enzymes: role in mutagen sensitivity.

Carcinogenesis - 1 Jun 2002

Tuimala Jarno, Szekely Gabor, Gundy Sarolta, Hirvonen Ari, Norppa Hannu

Abstract excerpt

Mutagen sensitivity, measuring the extent of chromosome damage induced by an in vitro treatment of peripheral lymphocytes with bleomycin, has been associated with an increased risk of various human cancers. Sensitivity to bleomycin appears to have high heritability and is usually considered to reflect individual capacity to repair DNA lesions. Another potential contributor to variation in bleomycin sensitivity...

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Source

Identifiers

PMID: 12082022
DOI: 10.1093/carcin/23.6.1003

Genes

XRCC1
GSTM1
GSTT1
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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