Article
Mutagen sensitivity as a biological marker of lung cancer risk in African Americans.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Mar 1995
Spitz M R, Hsu T C, Wu X, Fueger J J, Amos C I, Roth J A
Abstract excerpt
Cigarette smoking is the major determinant of lung cancer. However, only a fraction of smokers develops lung cancer; genetically determined susceptibility factors seem to play an important role also. Previous case-control studies have shown that in vitro bleomycin-induced mutagen sensitivity is an independent risk factor for head-and-neck cancers, and preliminary data suggest a similar association with lung...
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