Article
Mutagen sensitivity as a marker of cancer susceptibility.
Journal of cellular biochemistry. Supplement - 1 Jan 1996
Spitz M R, Wu X, Jiang H, Hsu T C
Abstract excerpt
Modulation of environmental exposures by host genetic factors may explain interindividual variation in susceptibility to carcinogenesis. One determinant of susceptibility is mutagen sensitivity measured by the frequency of bleomycin-induced breaks in an in vitro lymphocyte assay. Mutagen sensitivity is a significant predictor of aerodigestive tract cancer risk. In this case-control study of lung-cancer...
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