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Article

Feedback control of Set1 protein levels is important for proper H3K4 methylation patterns.

Cell reports - 27 Mar 2014

Soares Luis M, Radman-Livaja Marta, Lin Sherry G, Rando Oliver J, Buratowski Stephen

Abstract excerpt

Methylation of histone H3 lysine 4 by the Set1 subunit of COMPASS correlates with active transcription. Here, we show that Set1 levels are regulated by protein degradation in response to multiple signals. Set1 levels are greatly reduced when COMPASS recruitment to genes, H3K4 methylation, or transcription is blocked. The degradation sequences map to N-terminal regions that overlap a previously identified...

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Identifiers

PMID: 24613354
DOI: 10.1016/j.celrep.2014.02.017
PMCID: PMC3999964

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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