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Article

Histone trimethylation by Set1 is coordinated by the RRM, autoinhibitory, and catalytic domains.

The EMBO journal - 23 Mar 2005

Schlichter Alisha, Cairns Bradley R

Abstract excerpt

Trimethylation of lysine 4 of histone H3 occurs at the 5' end of active genes and is catalyzed by Set1 in Saccharomyces cerevisiae. Trimethylation requires histone H2B ubiquitylation and the PAF1 complex, which are linked to transcription elongation, but how they activate Set1 is not known. Set1 also bears several conserved domains with uncharacterized contributions to activity. Here, we isolated dominant...

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Source

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Identifiers

PMID: 15775977
DOI: 10.1038/sj.emboj.7600607
PMCID: PMC556409

Genes

PAF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Histone trimethylation by Set1 is coordinated by the RRM, autoinhibitory, and catalytic domains.PMID 15775977Read ↗

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