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Article

Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6.

The Journal of biological chemistry - 9 Aug 2002

Dover Jim, Schneider Jessica, Tawiah-Boateng Mary Anne, Wood Adam, Dean Kimberly, Johnston Mark, Shilatifard Ali

Abstract excerpt

The DNA of eukaryotes is wrapped around nucleosomes and packaged into chromatin. Covalent modifications of the histone proteins that comprise the nucleosome alter chromatin structure and have major effects on gene expression. Methylation of lysine 4 of histone H3 by COMPASS is required for silencing of genes located near chromosome telomeres and within the rDNA (Krogan, N. J, Dover, J., Khorrami, S., Greenblatt,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12070136
DOI: 10.1074/jbc.C200348200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6.PMID 12070136Read ↗

A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation.Semantic proximity Read ↗

Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast.Semantic proximity Read ↗

Catalytic and functional roles of conserved amino acids in the SET domain of the S. cerevisiae lysine methyltransferase Set1.Semantic proximity Read ↗

Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1.Semantic proximity Read ↗

Novel trans-tail regulation of H2B ubiquitylation and H3K4 methylation by the N terminus of histone H2A.Semantic proximity Read ↗

Simultaneous mutation of methylated lysine residues in histone H3 causes enhanced gene silencing, cell cycle defects, and cell lethality in Saccharomyces cerevisiae.Semantic proximity Read ↗

Ubiquitylation of the COMPASS component Swd2 links H2B ubiquitylation to H3K4 trimethylation.Semantic proximity Read ↗

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Evidence that Set1, a factor required for methylation of histone H3, regulates rDNA silencing in S. cerevisiae by a Sir2-independent mechanism.Semantic proximity Read ↗

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