Article
Uncleaved TFIIA is a substrate for taspase 1 and active in transcription.
Molecular and cellular biology - 1 Apr 2006
Zhou Huiqing, Spicuglia Salvatore, Hsieh James J-D, Mitsiou Dimitra J, Høiby Torill, Veenstra Gert Jan C, Korsmeyer Stanley J, Stunnenberg Hendrik G
Abstract excerpt
In higher eukaryotes, the large subunit of the general transcription factor TFIIA is encoded by the single TFIIAalphabeta gene and posttranslationally cleaved into alpha and beta subunits. The molecular mechanisms and biological significance of this proteolytic process have remained obscure. Here, we show that TFIIA is a substrate of taspase 1 as reported for the trithorax group mixed-lineage leukemia protein. We...
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