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Article

The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation.

Molecular cell - 1 Mar 2003

Krogan Nevan J, Dover Jim, Wood Adam, Schneider Jessica, Heidt Jonathan, Boateng Marry Ann, Dean Kimberly, Ryan Owen W, Golshani Ashkan, Johnston Mark, Greenblatt Jack F, Shilatifard Ali

Abstract excerpt

Methylation of histone proteins is one of their many modifications that affect chromatin structure and regulate gene expression. Methylation of histone H3 on lysines 4 and 79, catalyzed by the Set1-containing complex COMPASS and Dot1p, respectively, is required for silencing of expression of genes located near chromosome telomeres in yeast. We report that the Paf1 protein complex, which is associated with the...

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PMID: 12667454
DOI: 10.1016/s1097-2765(03)00091-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation.PMID 12667454Read ↗

Dot1 regulates nucleosome dynamics by its inherent histone chaperone activity in yeast.Semantic proximity Read ↗

Effects of the Paf1 complex and histone modifications on snoRNA 3'-end formation reveal broad and locus-specific regulation.Semantic proximity Read ↗

The Double-Strand Break Landscape of Meiotic Chromosomes Is Shaped by the Paf1 Transcription Elongation Complex in Saccharomyces cerevisiae.Semantic proximity Read ↗

Dot1p modulates silencing in yeast by methylation of the nucleosome core.Semantic proximity Read ↗

Yeast Swd2 is essential because of antagonism between Set1 histone methyltransferase complex and APT (associated with Pta1) termination factor.Semantic proximity Read ↗

Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association.Semantic proximity Read ↗

The Paf1 complex has functions independent of actively transcribing RNA polymerase II.Semantic proximity Read ↗

H3K4 di- and trimethylation modulate the stability of RNA polymerase II pausingSemantic proximity Read ↗

Catalytic and functional roles of conserved amino acids in the SET domain of the S. cerevisiae lysine methyltransferase Set1.Semantic proximity Read ↗

Feedback control of Set1 protein levels is important for proper H3K4 methylation patterns.Semantic proximity Read ↗

Paf1 and Ctr9, core components of the PAF1 complex, maintain low levels of telomeric repeat containing RNA.Semantic proximity Read ↗

Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6.Semantic proximity Read ↗

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