Article
SETBP1 is dispensable for normal and malignant hematopoiesis.
Leukemia - 1 Sept 2023
Tanaka Atsushi, Nishimura Koutarou, Saika Wataru, Kon Ayana, Koike Yui, Tatsumi Hiromi, Takeda June, Nomura Masaki, Zang Weijia, Nakayama Manabu, Matsuda Masashi, Yamazaki Hiromi, Fukumoto Miki, Ito Hiromi, Hayashi Yasutaka, Kitamura Toshio, Kawamoto Hiroshi, Takaori-Kondo Akifumi, Koseki Haruhiko, Ogawa Seishi, Inoue Daichi
Abstract excerpt
SETBP1 is a potential epigenetic regulator whose hotspot mutations preventing proteasomal degradation are recurrently detected in myeloid malignancies with poor prognosis. It is believed that the mutant SETBP1 exerts amplified effects of wild-type SETBP1 rather than neomorphic functions. This indicates that dysregulated quantitative control of SETBP1 would result in the transformation of hematopoietic cells....
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