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Article

UpSET recruits HDAC complexes and restricts chromatin accessibility and acetylation at promoter regions.

Cell - 7 Dec 2012

Rincon-Arano Hector, Halow Jessica, Delrow Jeffrey J, Parkhurst Susan M, Groudine Mark

Abstract excerpt

Developmental gene expression results from the orchestrated interplay between genetic and epigenetic mechanisms. Here, we describe upSET, a transcriptional regulator encoding a SET domain-containing protein recruited to active and inducible genes in Drosophila. However, unlike other Drosophila SET proteins associated with gene transcription, UpSET is part of an Rpd3/Sin3-containing complex that restricts...

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Share to Acetylation
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drosophila Proteins

Share to Gene Knockdown Techniques

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Share to Promoter Regions, Genetic

Source

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Identifiers

PMID: 23177352
DOI: 10.1016/j.cell.2012.11.009
PMCID: PMC3518625

Genes

SET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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