Article
Single nucleotide polymorphisms of DNA base-excision repair genes (APE1, OGG1 and XRCC1) associated with breast cancer risk in a Chinese population.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2014
Luo Hao, Li Zheng, Qing Yi, Zhang Shi-Heng, Peng Yu, Li Qing, Wang Dong
Abstract excerpt
Altered DNA repair capacity can result in increased susceptibility to cancer. The base excision repair (BER) pathway effectively removes DNA damage caused by ionizing radiation and reactive oxidative species (ROS). In the current study, we analyzed the possible relation of polymorphisms in BER genes, including 8-oxoguanine DNA glycosylase (OGG1), apurinic/apyrimidinic endonuclease 1 (APE1), and X-ray repair...
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