Association Between Seven Selected Genetic Polymorphisms in DNA Repair-Related Genes and Breast Cancer Risk: Evidence from a Comprehensive Meta-analysis Including 96 Studies.

doi:10.1007/s10528-025-11181-5

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Association Between Seven Selected Genetic Polymorphisms in DNA Repair-Related Genes and Breast Cancer Risk: Evidence from a Comprehensive Meta-analysis Including 96 Studies.

Biochemical genetics - 1 Apr 2026

Ruan Jiangyi, Zhou Hang, E Zhengyu, Chu Yuping, Zhang Shujing, Liao Jiaxi, Zhou Weiguang, Chen Bifeng

Abstract excerpt

Impaired DNA repair is a major driver for carcinogenesis and could promote aggressive cancer biology. Mammalian cells have evolved highly conserved DNA repair machinery to process DNA damage and maintain genomic integrity. Until now, multiple genetic polymorphisms in DNA repair-related genes have been extensively examined for their contribution to breast cancer (BC) risk, including BRCA1 gene rs799917, RAD51 gene...

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Identifiers

PMID: 40586826
DOI: 10.1007/s10528-025-11181-5

Genes

ERCC1
RAD51
XRCC1
BRCA1
XPC
XRCC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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