Article
Reverse-phase protein array profiling of oropharyngeal cancer and significance of PIK3CA mutations in HPV-associated head and neck cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2014
Sewell Andrew, Brown Brandee, Biktasova Asel, Mills Gordon B, Lu Yiling, Tyson Darren R, Issaeva Natalia, Yarbrough Wendell G
Abstract excerpt
PURPOSE: Human papilloma virus (HPV)-associated (HPV+) oropharyngeal squamous cell carcinomas (OPSCC) have different molecular and biologic characteristics and clinical behavior compared with HPV-negative (HPV-) OPSCC. PIK3CA mutations are more common in HPV(+) OPSCC. To define molecular differences and tumor subsets, protein expression and phosphorylation were compared between HPV(+) and HPV(-) OPSCC and between...
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